Use concomitantly with caution; consider using lower initial and maintenance dosages of atorvastatin; carefully monitor patients for unexplained muscle pain, tenderness, or weakness, particularly during initial months of atorvastatin therapy or following an increase in dosage of either drug 1.
Effects of combination lipid therapy in type 2 diabetes mellitus. Comparison of effects of simvastatin versus atorvastatin on high-density lipoprotein cholesterol and apolipoprotein A-I levels. Dosage modification not necessary in patients with renal impairment.
Atorvastatin is a selective, competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxymethylglutaryl-coenzyme A to mevalonate, a precursor of sterols, including cholesterol. LIPITOR significantly reduced the rate of coronary events [either fatal coronary heart disease 46 events in the placebo group vs.
The low-density lipoprotein pathway and its relation to atherosclerosis. North Chicago, IL; Mar. The primary analysis was the time to first occurrence of the primary endpoint. Other fibric acid derivatives e. You need some cholesterol for good health, but too much is not good for you.
Long-term effects of pravastatin on plasma concentration of C-reactive protein. In this multicenter, placebo-controlled, double-blind clinical trial, subjects were randomly allocated to either LIPITOR 10 mg daily or placebo in a 1: LIPITOR is for adults and children over 10 whose cholesterol does not come down enough with exercise and a low-fat diet alone.
Potential pharmacokinetic interaction increased bioavailability of atorvastatin. Nasopharyngitis, arthralgia, diarrhea, pain in extremity, urinary tract infection, dyspepsia, nausea, musculoskeletal pain, muscle spasms, myalgia, insomnia, pharyngolaryngeal pain.
Increased atorvastatin peak plasma concentration and AUC; increased risk of myopathy or rhabdomyolysis 1. Int J Clin Pract. Periodic creatine phosphokinase CPK determinations may be considered in such situations, but there is no assurance that such monitoring will prevent the occurrence of severe myopathy.
Additionally all patients had at least 3 of the following cardiovascular risk factors: Atorvastatin crosses the rat placenta and reaches a level in fetal liver equivalent to that of maternal plasma.
East Hanover, NJ; Apr. Ask your doctor or pharmacist for a complete list. Extensively metabolized in the liver, 1 mainly by CYP3A4, 1 to active metabolites.
Paper presented at 66th Congress of the European Atherosclerosis Society. Bronchitis, rhinitis, pneumonia, dyspnea, asthma, epistaxis. Adjunct to nondrug therapies e. Use concomitantly with caution; use lowest necessary dosage of atorvastatin 1 Nelfinavir: Effects of simvastatin and atorvastatin administration on insulin resistance and respiratory quotient in aged dyslipidemic non-insulin dependent diabetic patients.