Nevertheless, these studies demonstrated a reduction in cardiovascular event risk in patients with NDD early-stage CKD receiving statins Table 2. It is time for McKillop to desist from this unprincipled campaign. Try the new test version at https: The Study of Heart and Renal Protection SHARP was a randomized double-blind trial that investigated the effect of simvastatin 20 mg plus ezetimibe 10 mg versus matching placebo on atherosclerotic events in patients with CKD and no known history of myocardial infarction or coronary revascularization, including patients not on dialysis 18 Table 2.
Choose courses based on your needs. Rosuvastatin 10 mg oral dose administered once daily for 52 weeks Other Name: Business of Medicine Navigate the complex business, legal, and ethical arenas towards building and maintaining a successful medical practice.
The results of the PLANET I study, in which eGFR declined in diabetic, proteinuric patients receiving rosuvastatin, raise the question about whether to use this drug in diabetic, proteinuric patients with CKD, 47 and it has been suggested that the high concentration of rosuvastatin and its metabolites in the kidney may increase proteinuria and worsen renal function, especially at high doses.
National Library of Medicine U. Listing a study does not mean it has been evaluated by the U. National Institutes of Health U. To date, no studies have investigated cardiovascular outcomes in patients undergoing peritoneal dialysis.
Reproduced with permission of American Society of Nephrology. Not a Medscape Member? The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Sidney Wolfe explains why he thinks the drug should have been withdrawn and why it should not be used. I was an ordinary doctor until I found Medscape. Hyperlipidemia Proteinuria Diabetes Mellitus.
N Engl J Med ; JAMA ; For general information, Learn About Clinical Studies. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.
Disease and Condition Articles. Data on the effect of statin therapy on renal parameters in patients with CKD also vary Table 3. Read our disclaimer for details.