CYP2D6 extensive metabolizers had low serum concentrations of tolterodine and high concentrations of the active metabolite 5-HMT, while poor metabolizers had high concentrations of tolterodine and negligible active metabolite concentrations.
Diokno AC, et al. In the event of difficulty in breathing, upper airway obstruction, or fall in blood pressure, DETROL LA should be discontinued and appropriate therapy promptly provided. Patients should be monitored for signs of anticholinergic CNS effects, particularly after beginning treatment or increasing the dose. The study was extremely short in its design and there were no quality of life data by which the clinical relevance of the findings might be judged.
However the number of patients discontinuing from the study in both groups due to adverse events was comparable. Following an analysis of safety in subjects receiving at least one dose of study medication in younger and older subjects, the most common adverse events were dry mouth For a complete list, ask your doctor or pharmacist.
Overdosage with DETROL can potentially result in severe central anticholinergic effects and should be treated accordingly. Please complete the fields below. There was likewise no difference between placebo and tolterodine in reduction of urgency incontinence episodes and all incontinence episodes.
At these doses, the AUC values were about to fold higher than in humans. Tolterodine ER demonstrated an improved efficacy for reducing urge incontinence episodes and a lower frequency of dry mouth compared with the existing IR twice-daily formulation.
Advise patients not to drive or operate heavy machinery until the drug's effects have been determined. The pK a value is 9. This misunderstanding leads to a delay in people seeking treatment for their symptoms and to clinicians failing to treat patients either seriously or at all, prolonging the suffering associated with the condition. Tolterodine is extensively metabolized by the liver following oral dosing.
Tolterodine, a new antimuscarinic agent: EP Vantage brings a fresh view on pharma and biotech with incisive daily analysis, powered by Evaluate Ltd. Please click the following link to register and submit an upgrade request, so that a member of our sales team can contact you to discuss your requirements. The majority of instances of dry mouth were mild and moderate in intensity.