Antifungals D01 and J Butenafine is classified as FDA pregnancy risk category C. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient.
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The inhibition of squalene monooxygenase creates a deficiency in ergosterol, a component of fungal membranes necessary for normal cell growth. Data not available Comments: The primary metabolite found in the urine is formed through hydroxylation at the terminal t-butyl side-chain. Butenafine is applied topically.
This article needs additional citations for verification. You may also report side effects at http: We comply with the HONcode standard for trustworthy health information - verify here. Butenafine hydrochloride is an odorless white crystalline powder that is freely soluble in methanolethanoland chloroformand slightly soluble in water.
Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Views Read Edit View history. Four weeks after cessation of treatment, the plasma butenafine HCl concentration ranged from undetectable to 0.
Instruct nursing mothers to avoid topical application to the breast, as this would be expected to increase infant exposure. If a patient shows no clinical improvement after the treatment period, the diagnosis should be reviewed.
Depending upon the concentration of the drug and the fungal species tested, butenafine may be fungicidal in vitro; however, the clinical relevance of these data are unknown. Tinea Cruris clotrimazole topicalketoconazole topicalLotrisoneterbinafine topicalLamisilciclopirox topicalmiconazole topicalMore For the topical treatment of interdigital tinea pedis due to susceptible organisms such as Epidermophyton floccosumTrichophyton mentagrophytesTrichophyton rubrumTrichophyton tonsurans, or Malassezia furfur.
Butenafine HCl is a white, odorless, crystalline powder.