Administer once daily at bedtime. The benefits of the use of lovastatin in patients taking verapamil should be carefully weighed against the risks of this combination. You may need to stay for at least 48 hours in a hospital for observation and care. The data for verapamil improving maximum walking distance in patients with intermittent claudication are inconclusive; however, verapamil may be an option for some patients who have failed or not tolerated other therapies.
You've chosen to add topics from the topic group to your selected topics. Lower starting and maintenance doses of other CYP3A4 substrates e.
An interaction is when a substance changes the way a drug works. According to the OBRA guidelines, antihypertensive regimens should be individualized to achieve the desired outcome while minimizing adverse effects.
Calan SR Description
Verapamil should be used with caution in patients with neuromuscular disease. Verapamil may increase the amount of alcohol in your blood and make alcohol effects continue longer.
The first dose response acute postural hypotension of prazosin may be exaggerated in patients who are receiving beta-adrenergic blockers, diuretics, or other antihypertensive agents.
Adjust dosage based on clinical response. Clarithromycin may decrease the clearance of calcium-channel blockers e. Maintenance and digitalization doses should be reduced when verapamil is administered, and the patient should be carefully monitored to avoid over- or under-digitalization.
Additionally, bromocriptine should be used cautiously with other medications known to lower blood pressure such as verapamil. Experience with fingolimod in patients receiving concurrent therapy with drugs that slow the heart rate or atrioventricular conduction is limited. Minor In a few reported cases, coadministration of verapamil with aspirin, ASA has led to increased bleeding times greater than observed with aspirin alone.
All Interactions Sort By: Coadministration is contraindicated in patients with renal or hepatic impairment because colchicine accumulation may be greater in these populations. Co-administration with verapamil may lead to an increase in serum levels of drugs that are CYP3A4 substrates, such as fentanyl. Overview Side Effects Dosage More. Many patients will require more than one drug to achieve blood pressure goals.
Moderate The concomitant administration of tamsulosin with other antihypertensive agents can cause additive hypotensive effects. It may also cause other side effects. OR Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.