It is not known if dosage adjustments are required in patients requiring concurrent therapy, but patients should be monitored for increased anticholinergic effects.
Tolterodine is extensively metabolized by the liver following oral dosing. The most commonly reported adverse reaction was dry mouth, which occurred in A total of paediatric patients on tolterodine and on placebo aged years with urinary frequency and urge urinary incontinence were studied. Thanks for subscribing and having us along on your health and wellness journey.
The net antimuscarinic activity is expected to be similar in both extensive and poor metabolizers. Eribulin has also been associated with QT prolongation. The adverse reaction information from clinical trials does, however, provide a basis for identifying the adverse events that appear to be related to drug use and approximating rates.
Moderate Tricyclic antidepressants TCAs should be used cautiously and with close monitoring with tolterodine.
Selected from data included with permission and copyrighted by Boots UK Limited. DetrolDetrol LA. This is only a brief summary of general information about this medicine. Never try to catch up by taking two doses at once. Major Due to the potential for QT prolongation and torsade de pointes TdPcaution is advised when administering fluconazole with tolterodine. Anticholinergics may precipitate urinary retention in patients with preexisting urinary tract obstruction or prostatic hypertrophy, so caution is warranted.
Do not start, stop, or change the dose of any drug without checking with your doctor. Thank you for sharing your feedback.
Consult your pharmacist or local waste disposal company. Tolterodine was also negative in vivo in the bone marrow micronucleus test in the mouse.
What do I need to tell my doctor BEFORE I take Tolterodine Tablets?
Moderate Administering tolterodine with elbasvir; grazoprevir may result in elevated tolterodine plasma concentrations. If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist. In Phase 1, multiple-dose studies in which tolterodine immediate-release 4 mg 2 mg bid was administered, serum concentrations of tolterodine and of the 5-hydroxymethyl metabolite were similar in healthy elderly volunteers aged 64 through 80 years and healthy young volunteers aged less than 40 years.
When to call the doctor. Food does not influence the exposure to the unbound tolterodine and the active 5-hydroxymethyl metabolite in extensive metabolisers, although the tolterodine levels increase when taken with food. After oral administration, tolterodine is metabolized in the liver, resulting in the formation of the 5-hydroxymethyl derivative, a major pharmacologically active metabolite.
Clarithromycin is associated with an established risk for QT prolongation and TdP. In mice, there was no effect of tolterodine on fertility or reproductive function.